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KMID : 1011920200210010003
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International Journal of Arrhythmia
2020 Volume.21 No. 1 p.3 ~ p.3
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Differences in anticoagulation strategy and outcome in atrial fibrillation patients with chronic kidney disease: a CODE-AF registry study
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Choi Yeon-Jik
Uhm Jae-Sun
Kim Tae-Hoon
Cha Myung-Jin
Lee Jung-Myung
Park Jun-Beom
Park Jin-Kyu
Kang Ki-Woon
Shim Jae-Min
Kim Jun
Park Hyung-Wook
Choi Eue-Keun
Kim Jin-Bae
Kim Chang-Soo
Lee Young-Soo
Joung Bo-Young
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Abstract
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Purpose: Dose reduction of non-vitamin K antagonist oral anticoagulants (NOACs) is indicated in patients with atrial fibrillation (AF) with renal impairment. This study investigated anticoagulation patterns and outcomes in patients with chronic kidney disease (CKD).
Materials and methods: In a prospective observational registry (CODE-AF), 3445 patients with non-valvular AF including 1129 with CKD (estimated glomerular filtration rate ≤?60 mL min?1 1.73 m?2) were identified between June 1, 2016, and July 3, 2017.
Results: Compared with patients with no-CKD, patients with CKD more frequently had a high stroke risk (94.9% vs. 67.0%, p?
Conclusion: CKD patients might have a high stroke risk and NOAC usage rate. The underdose rate of NOACs decreased in CKD patients, except for apixaban. Aspirin significantly increased minor bleeding in CKD patients.
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KEYWORD
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Atrial fibrillation, Anticoagulation, Kidney diseases, Stroke
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